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Heart conditions : Generally safe, but discuss if you have a history of heart failure

The level of significance may be higher if that data is obtained

sex-specific analyses have not been published, making definitive conclusions about safety in women premature

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Safety Considerations for Combining Weight Loss and Antidepressant Therapy Blood pressure monitoring becomes especially important when using semaglutide and bupropion together, since bupropion can moderately elevate systolic and diastolic readings in some patients

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